ʻO ka wehewehe pōkole:
Helu CAS: 27164-46-1
Kumu molekala: C14H15N8NaO4S3
kaumaha molekalale: 478.5
Hoʻolālā kemika:
| ʻIke Kumu | |
| inoa huahana | ʻO ka paʻakai sodium Cefazolin |
| CAS No. | 27164-46-1 |
| Ka nana aku | Keʻokeʻo a i ʻole ka pauka kristal keʻokeʻo |
| Papa | Papa Lapaʻau |
| Waihona | E mālama i kahi pōʻeleʻele, Inert ea, 2-8 ° C |
| Ola Pahu | 2 makahiki |
| Paʻa | Paʻa, akā paʻa paha ka wela - mālama i nā kūlana anuanu. Hiki ke ʻulaʻula ke ʻike ʻia i ka mālamalama - mālama i ka pōʻeleʻele. ʻAʻole kūpono me nā mea oxidizing ikaika. |
| Pūʻolo | 25kg/Drum |
Hōʻike huahana
He antibiotic semi synthetic i loaʻa nā cephalosporins i loko o ka mole o nā cephalosporins. Unuhi ʻia ʻo Xianfeng mycin. pili iā β－ʻO nā lāʻau lapaʻau lactam, ʻae β- ʻO nā derivatives o ka 7-aminocephalosporanic acid (7-ACA) i loko o nā lāʻau lapaʻau lactam he mau hana bactericidal like. Hiki i kēia ʻano lāʻau lapaʻau ke hoʻopau i ka paia cell o ka bacteria a pepehi iā lākou i ka wā hānau. He hopena koʻikoʻi kona ma luna o ka bacteria a aneane ʻaʻohe mea ʻona i ke kanaka, me nā mea maikaʻi e like me ka laulā antibacterial spectrum, ikaika antibacterial hopena, kū'ē i nā enzymes penicillin, a me ka liʻiliʻi o nā hopena maʻi i hoʻohālikelike ʻia me ka penicillin. No laila he antibiotic koʻikoʻi me ka hana kiʻekiʻe, haʻahaʻa haʻahaʻa, a me ka hoʻohana lapaʻau ākea. Ua hoʻomohala mua ʻia nā cephalosporins hanauna mua, me ka hana antibacterial ikaika i hoʻohālikelike ʻia me Chemicalbook, ʻoi aku ka liʻiliʻi o ka antibacterial spectrum, a ʻoi aku ka maikaʻi o nā hopena anti-Gram positive bacteria ma mua o ka Gram negative bacteria. Hana ʻia e Staphylococcus aureus β- Lactamase paʻa a hiki ke kāohi i ka hana ʻana o nā hua bacteria maikaʻi ʻole β- ʻAʻole paʻa nā lactamases a hiki ke hana ʻia e nā hua bacteria Gram he nui β- Ua pōʻino ʻia e nā lactamases. ʻO ka Cefazolin sodium he cephalosporin hanauna mua semi synthetic i loaʻa nā hopena antibacterial e kūʻē i nā hua bacteria gram-positive a me gram-negative. Hoʻohana maʻamau ia i nā maʻi o ka ʻōnaehana hanu, ka ʻōnaehana urogenital, ka ʻili palupalu o ka ʻili, ka iwi a me ka hui, a me nā ʻāpana biliary i hoʻokumu ʻia e ka maʻi bacteria, a me ka endocarditis, sepsis, pharyngeal a me nā maʻi pepeiao. He hana ikaika kona e kū'ē i nā hua bacteria gram-positive e like me Staphylococcus aureus a me Streptococcus (koe ʻole Enterococcus), a ʻoi aku ka maikaʻi ma mua o ka cephalosporins o ka hanauna ʻekolu.
Hoʻohana Kemika
ʻO Cefazolin (Ancef, Kefzol) kekahi o nā semisyntheticcephalosporins kahi i hoʻololi ʻia ai ka hana acetoxy C-3 e kahi heterocycle thiol-i loko o kēia, 5-methyl-2-thio-1,3,4-thiadiazole. Loaʻa pū kekahi i ka hui tetrazolylacetyl acylating. Ua hoʻokuʻu ʻia ʻo Cefazolin i ka makahiki 1973 ma ke ʻano he paʻakai paʻakai paʻakai wai. Hoʻoikaika wale ʻia e ka hoʻokele parenteral.
Hāʻawi ʻo Cefazolin i nā kiʻekiʻe o ka serum kiʻekiʻe, ʻoi aku ka lohi o ka renalclearance, a ʻoi aku ka hapalua o ke ola ma mua o nā cephalosporins mua. Aia ma kahi o 75% o ka protein paʻa i ka inplasma, ʻoi aku ka nui o ka waiwai ma mua o ka hapa nui o nā cephalosporins ʻē aʻe. Ma mua o ka in vitro a me nā noiʻi lapaʻau e hōʻike ana he ʻoi aku ka ikaika o ka cefazolin e kūʻē i ka bacilli Gram-negative akā ʻoi aku ka ikaika ma mua o ka cephalothin orcephaloridine. ʻO ka nui o ka loaʻa ʻana o ka thrombophlebitis ma hope o ka hoʻokele intravenous a me ka ʻeha ma ke kahua o ka intramuscular injection ʻike ʻia ka haʻahaʻa loa o ka parenteralcephalosporins.
