ʻO ka sodium Cefoperazone + ka sodium sulbactam

wehewehe:
ʻO Cefoperazone sodium + sulbactam sodium (1: 1/2: 1) he mea hoʻoikaika makua, β-lactamase inhibitor i hoʻokomo hou ʻia ma ke ʻano he 1: 1 hui pū me ka cefoperazone. E like me ka clavulanic acid, ka mea mua o kēia ʻano e hoʻokomo ʻia, hoʻonui ka sulbactam i ka maikaʻi o nā lāʻau antibiotic β-lactam e kūʻē i nā kuʻekuʻe.
Hoʻohana:
ʻO kahi mea pale β-lactamase semi-synthetic. Hoʻohana ʻia me ka hui pū me nā antibiotics β-lactam ma ke ʻano he antibacterial.
ʻO ka paʻakai sodium Cefoperazone he lāʻau antibiotic cephalosporin no ka pale ʻana i ka lawe ʻana o rMrp2-mediated [3H]E217βG me IC50 o 199 μM. Pahuhopu: Antibacterial Cefoperazone he sterile, semisynthetic, broad-spectrum, parenteral cephalosporin antibiotic no ka intravenous a intramuscular administration. Ma hope o ka lawelawe intravenous o 2 g o Cefoperazone, ua piʻi nā pae i ka serum mai 202μg / mL a i 375 μg / mL ma muli o ka manawa o ka hoʻokele lāʻau. Ma hope o ka hoʻokomo intramuscular o 2 g o Cefoperazone, ʻo ka mean peak serum pae he 111 μg / mL i nā hola 1.5. Ma 12 mau hola ma hope o ka hoʻopaʻa ʻana, ʻo ka nui o nā pae serum he 2 a 4 μg/mL. ʻO ka Cefoperazone he 90% paʻa i nā protein serum.