ʻO Ceftriaxone Sodium

ʻO Ceftriaxone sodium he β-lactamase-resistantcephalosporin me ka hapalua o ke ola serum lōʻihi loa. ʻElua mau mea e hoʻopili ai i ka lōʻihi o ka hana o ka ceftriaxone: ke kiʻekiʻe o ka protein i hoʻopaʻa ʻia i loko o ka plasma a me ka hoʻolohi ʻana i ka urinary excretion. Hoʻokuʻu ʻia ʻo Ceftriaxone i loko o ka bile a me ka mimi. ʻAʻole pili ka hoʻoheheʻe ʻana i kāna mimi e ka probenecid. ʻOiai ka haʻahaʻa haʻahaʻa o ka hāʻawi ʻana, hiki ia i ka wai cerebrospinal i ka ʻike ʻana i kūpono i ka maningitis. ʻIke ʻia nā pharmacokinetics nonlinear.
Loaʻa i ka Ceftriaxone kahi ʻōnaehana heterocyclic acidic nui ma ka hui 3-thiomethyl. Manaʻo ʻia kēia ʻano ringsystem dioxotriazine e hāʻawi i nā waiwai pharmacokinetic kūʻokoʻa o kēia mea hana. Ua hoʻopili ʻia ʻo Ceftriaxone me ka "sludge," a i ʻole pseudolithiasis, i loko o ka gallbladder a me ka duct bile maʻamau. Hiki ke loaʻa nā hōʻailona o ka cholecystitis i nā poʻe maʻi maʻalahi, ʻoi aku ka poʻe i loaʻa i ka lāʻau ceftriaxone lōʻihi a kiʻekiʻe paha. Ua ʻike ʻia ka mea hewa he calcium chelate.
Hōʻike ʻo Ceftriaxone i ka antibacterialactivity ākea ākea e kūʻē i nā mea ʻelua Gram-positive a me Gram-negative. He kūpaʻa loa ia i ka hapa nui o nā chromosomally a me nā plasmid-mediated β-lactamases. ʻO ka hana o ceftriaxone e kūʻē iā Enterobacter, Citrobacter, Serratia, indole-positiveProteus, a me Pseudomonas spp. he mea kupanaha loa. Maikaʻi nō hoʻi i ka mālama ʻana i nā maʻi gonorrhea me ka H. influenzae kūʻē i ka ampicillin akā ʻoi aku ka liʻiliʻi ma mua o ka cefotaxime e kūʻē i ka bacteria Gram-positive a me B.fragilis.