ʻO Clindamycin Phosphate Mea Maka

Hoʻohana ʻia ʻo Clindamycin phosphate ma luna wale nō a i hui pū ʻia me benzoyl peroxide i ka mālama ʻana i ka inflammatory acne vulgaris. I ke kaupaona ʻana i nā pono kūpono o ka lāʻau clindamycin topical, pono e noʻonoʻo ʻia ka hiki ke loaʻa nā hopena koʻikoʻi GI e pili ana i ka lāʻau. Pono e hoʻokaʻawale ʻia ka lāʻau lapaʻau o ka acne vulgaris a hoʻololi pinepine ʻia ma muli o ke ʻano o nā ʻeha ʻeha e ulu nui a me ka pane ʻana i ka lāʻau lapaʻau. ʻO nā lāʻau anti-infectives maʻamau, me ka clindamycin, ka mea maʻamau i ka mālama ʻana i ka maʻi ʻeha ʻeha a me ka haʻahaʻa. Eia naʻe, hiki i ka hoʻohana ʻana i nā lāʻau anti-infective topical e like me ka monotherapy ke alakaʻi i ke kūʻē bacteria; pili kēia kū'ē me ka emi ʻana o ka pono lapaʻau. Hōʻike nā hopena o nā noiʻi lapaʻau i ka hopena o ka hui pū ʻana i ka hōʻemi ʻana i nā helu lesion āpau o 50-70%.

ʻO Clindamycin 2-phosphate ka paʻakai o clincamycin, he lincosamide semi-synthetic. Hoʻomākaukau ʻia ka paʻakai e ka phosphorylation koho o ka 2-hydroxy moiety o ke kō o clindamycin. Hāʻawi ka hoʻokomo ʻana i ka phosphate i ka hoʻomaikaʻi ʻana i ka solubility no nā hana injectable. E like me nā lālā ʻē aʻe o ka ʻohana lincosamide, ʻo clindamycin 2-phosphate kahi lāʻau lapaʻau ākea ākea me ka hana kūʻē i nā maʻi maʻi anaerobic a me nā protozoans. Hana ʻo Clindamycin ma ka hoʻopaʻa ʻana i ka subunit ribosomal 23S, kaohi ʻana i ka synthesis protein.