ʻO ka wehewehe pōkole:
Helu CAS:1264-72-8
ʻO ke kumu molekala:2(C52H98N16O13).5(H2SO4)
kaumaha molekala:2801.27
Hoʻolālā kemika:
| ʻIke Kumu | |
| inoa huahana | Colistin sulfate |
| Papa | Papa Hanai |
| Ka nana aku | Keʻokeʻo a aneane keʻokeʻo, pauka hygroscopic |
| Hoʻāʻo | 99% |
| Ola ola | 2 makahiki |
| Hoʻopili | 20kg / pahu pahu 20kg / pahu |
| Kūlana | E mālama i ka -20 ℃ no hoʻokahi makahiki（Pauda） |
ʻO ka wehewehe ʻana o ka huahana
ʻO Colistin he cyclic cationic decapeptide i hoʻopili ʻia i kahi kaulahao ʻaoʻao ʻaoʻao momona, aia ia i kahi pūʻulu o nā peptides antimicrobial bacterial i hana like. ʻO Colistin sulfate kahi lāʻau antibiotic polypeptide e kāohi ana i ka bacteria gram-negative ma o ka hoʻopaʻa ʻana i nā lipopolysaccharides a me nā phospholipids i loko o ka membrane cell waho o nā bacteria gram-negative.
ʻO Colistin sulfate, ʻike ʻia hoʻi he colistin sulfate, Christian (Colistin), Polymyxin E (Polymyxin E), antiphytin, keʻokeʻo a aneane keʻokeʻo pauka, ʻaʻala ʻole, ʻawaʻawa ʻono moistness, hiki ke hoʻoheheʻe ʻia i ka wai, hiki ke hoʻoheheʻe ʻia i ka methanol, ethanol, aneane hiki ʻole ke hoʻoheheʻe ʻia i loko. acetone, etera, alkali noa hiki ke hoʻoheheʻe iki ʻia i ka wai. Paʻa i ka pae PH3-7.5. Hana ʻia ka Mycolistin sulfate e Bacillus polymyxoides, nona ka hopena antibacterial ikaika i ka maʻi bacteria gram-negative. Hoʻohana ʻia ia e mālama i nā maʻi ʻōpū i hoʻokumu ʻia e ka bacteria gram-negative, a hoʻohana ʻia ma ke ʻano he meaʻai meaʻai me ka hoʻonui ʻana i ka hopena ulu. ʻOi aku ka maikaʻi o ka hui pū ʻana o ka hopena sulfadiazine.
Hana o ka huahana
Ua hoʻomaikaʻi ʻo Colistin sulfate granules i ka paʻa o ka potency i ka hānai a hōʻike i ka solubility kiʻekiʻe ʻoiai ke hana ʻia me ka ʻole o ka hoʻohana ʻana i kekahi mea lawe ukana a i ʻole nā mea hana kūikawā. ʻO ka mea kikoʻī, ʻo nā granules colistin sulfate i loko o ka colistin sulfate a loaʻa nā ʻāpana ʻāpana o 150 a 1500m, kahi ʻāpana kikoʻī o 40 a 500 cm2/g, kahi manawa hoʻomaʻemaʻe o 5 mau minuke a i ʻole a me kahi maʻamau o 10% a i lalo.
Pharmacodynamics
ʻO Colistin kahi lāʻau antibiotic polymyxin. ʻO nā polymyxins nā polypeptides cationic e hoʻopau i ka membrane cell bacteria ma o kahi ʻano mea holoi. Me ka hoʻomohala ʻana o nā mea ʻawaʻawa liʻiliʻi, e like me nā penicillins extended-spectrum a me cephalosporins, ua haʻalele nui ʻia ka hoʻohana ʻana o ka polymyxin parenteral, koe wale no ka mālama ʻana i nā maʻi pulmonary multidrug-resistant i nā maʻi me ka cystic fibrosis.
