ʻO ka wehewehe pōkole:
Helu CAS: 15687-27-1
Huina mole: C13H18O2
Kaumaha molekula: 206.28
Hoʻolālā kemika:
| ʻIke Kumu | |
| inoa huahana | Ibuprofen |
| CAS No. | 15687-27-1 |
| kalakala | Keʻokeʻo a keʻokeʻo |
| Puka | Ka pauda kristal |
| Ka hoʻoheheʻe | ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai, hiki ke hoʻoheheʻe ʻia i ka acetone, i ka methanol a me ka methylene chloride. E hoʻoheheʻe ʻia i loko o nā hopena dilute o ka alkali hydroxides a me nā carbonates. |
| Hiki i ka wai | hiki ole ke hooheheeia |
| Paʻa | Paʻa. Hiki ke puhi. ʻAʻole kūpono me nā mea oxidizing ikaika |
| Ola Pahu | 2 Ypepeiao |
| Pūʻolo | 25kg/Drum |
wehewehe
IAia ka buprofen i kahi analgesic anti-inflammatory non-steroidal. Loaʻa iā ia ka hopena anti-inflammatory, analgesic a me antipyretic me ka liʻiliʻi o nā hopena ʻino. Ua hoʻohana nui ʻia ma ka honua, ʻo ia nā lāʻau lapaʻau kūʻai maikaʻi loa ma ka honua. ʻO ia, me ka aspirin a me ka paracetamol i helu ʻia e like me nā huahana analgesics antipyretic nui ʻekolu. I ko mākou ʻāina, hoʻohana nui ʻia i ka hoʻohaʻahaʻa ʻana i ka ʻeha a me ka anti-rheumatism, a me nā mea ʻē aʻe. He ʻumi o nā hui lāʻau lapaʻau i kūpono no ka hana ʻana i ka ibuprofen ma Kina. Akā ʻo ka hapa nui o nā kūʻai kūʻai kūloko o ka ibuprofen ua noho ʻia e Tianjin Sino-US Company.
Ua ʻike pū ʻia ka Ibuprofen e Kauka Stewart Adams (ma hope ua lilo ʻo ia i kumu aʻoaʻo a lanakila i ka Medal of the British Empire) a me kāna hui me CoLinBurrows a me Kauka John Nicholson. ʻO ka pahuhopu o ka noiʻi mua ʻana, ʻo ia ka hoʻomohala ʻana i kahi "super aspirin" e loaʻa ai kahi ʻano ʻē aʻe no ka mālama ʻana i ka maʻi rumatika i hoʻohālikelike ʻia me ka aspirin akā me nā hopena ʻino. No nā lāʻau lapaʻau ʻē aʻe e like me ka phenylbutazone, ʻoi aku ka nui o ka hopena o ka hoʻopau ʻana i ka adrenal a me nā hanana ʻino ʻē aʻe e like me ka maʻi ʻeha o ka ʻōpū. Ua hoʻoholo ʻo Adams e ʻimi i kahi lāʻau lapaʻau me ke kūpaʻa maikaʻi o ka ʻōpū, he mea nui loa ia no nā lāʻau anti-inflammatory non-steroidal āpau.
ʻO nā lāʻau lapaʻau Phenyl acetate ua hoʻāla i ka hoihoi o nā kānaka. ʻOiai ua ʻike ʻia kekahi o kēia mau lāʻau lapaʻau e pili ana i ka maʻi ʻeha ma muli o ka hoʻāʻo ʻana o ka ʻīlio, ua ʻike ʻo Adams no ka lōʻihi o ka hapalua o ke ola o ka hoʻomaʻemaʻe lāʻau. I loko o kēia papa o nā lāʻau lapaʻau aia kahi pūhui - ibuprofen, he pōkole ka hapalua o ke ola, e mālama ana i nā hola 2 wale nō. Ma waena o nā lāʻau lapaʻau ʻē aʻe i hoʻopaʻa ʻia, ʻoiai ʻaʻole ia ka maikaʻi loa, ʻo ia ka mea palekana loa. I ka makahiki 1964, ua lilo ka ibuprofen i mea hoʻohiki maikaʻi loa i ka aspirin.
Nā hōʻailona
ʻO kahi pahuhopu maʻamau i ka hoʻomohala ʻana i nā lāʻau ʻeha a me ka ʻeha ʻana ʻo ia ka hana ʻana i nā pūhui i hiki ke mālama i ka ʻāʻī, ke kuni, a me ka ʻeha me ka ʻole e hoʻopilikia i nā hana physiological ʻē aʻe. ʻO nā mea hoʻomaha ʻeha maʻamau, e like me ka aspirin a me ka ibuprofen, ke kāohi i ka COX-1 a me COX-2. ʻO ka ʻōlelo kikoʻī o ka lāʻau lapaʻau e pili ana i ka COX-1 versus COX-2 e hoʻoholo i ka hiki ke loaʻa nā hopena ʻino. ʻO nā lāʻau lapaʻau me ka kikoʻī nui loa e pili ana i ka COX-1 e ʻoi aku ka nui o ka hiki ke hana i nā hopena ʻino. Ma ka hoʻopau ʻana i ka COX-1, hoʻonui nā mea hoʻomaha ʻeha nonselective i ka manawa o nā hopena ʻaoʻao maikaʻi ʻole, ʻoi aku ka nui o nā pilikia digestive e like me ka ʻōpū ʻōpū a me ke kahe o ka ʻōpū. ʻO nā mea hoʻopaneʻe COX-2, e like me Vioxx a me Celebrex, e hoʻopau i ka COX-2 a ʻaʻole e hoʻopilikia i ka COX-1 i nā ʻano i kuhikuhi ʻia. Ua kuhikuhi nui ʻia nā mea hoʻopale COX-2 no ka maʻi ʻeha a me ka hōʻeha ʻeha. I ka makahiki 2004, ua hoʻolaha ka Food and Drug Administration (FDA) i ka piʻi ʻana o ka pilikia o ka hōʻeha ʻana o ka naʻau a me ka hahau ʻana i pili pū me kekahi mau mea paʻa COX-2. Ua alakaʻi kēia i nā hōʻailona hōʻailona a me ka wehe ʻana i nā huahana mai ka mākeke e nā mea hana lāʻau; no ka laʻana, ua lawe ʻo Merck iā Vioxx mai ka mākeke i ka makahiki 2004. ʻOiai ke kāohi nei ʻo ibuprofen i ka COX-1 a me COX-2, he mau manawa ka kikoʻī i ka COX-2 i hoʻohālikelike ʻia me ka aspirin, e hoʻohua ana i nā hopena ʻaoʻao o ka ʻōpū..
