ʻO ka wehewehe pōkole:
Helu CAS:51322-75-9
ʻAno molekala:C9H8ClN5S
kaumaha molekala:253.71
Hoʻolālā kemika:
| ʻIke Kumu | |
| inoa huahana | ʻO Tizanidine |
| Papa | Papa lāʻau lapaʻau |
| Ka nana aku | Pauda keʻokeʻo |
| Hoʻāʻo | 99% |
| Ola ola | 2 makahiki |
| Hoʻopili | 25kg / pahu |
| Kūlana | E mālama i ka -20°C |
Papa kuhikuhi
ʻO Tizanidine kahi imidazoline ʻelua o ka nitrogen heterocyclic pentene derivative. Ua like ke ano me ka clonidine. I ka makahiki 1987, ua helu mua ʻia ʻo ia ma Finland ma ke ʻano he kikowaena adrenalin α2 receptor agonist. I kēia manawa, hoʻohana ʻia ia ma ke ʻano he mea hoʻomaha hoʻomaha o ka ʻiʻo ma ke keʻena. Hiki ke hoʻohana ʻia no ka mālama ʻana i nā ʻiʻo ʻehaʻeha, e like me ka ʻāʻī waist syndrome a me ka torticollis. Hiki ke hoʻohana ʻia no ka mālama ʻana i ka ʻeha postoperative, e like me ka disc herniation a me ka ʻāʻī ʻāʻī. Loaʻa ia mai ka ankylosis o nā maʻi neurological, e like me ka sclerosis lehulehu, ka myelopathy maʻi, ka maʻi cerebrovascular a me nā mea ʻē aʻe.
Hana
Hoʻohana ʻia ia e hōʻemi i ka ʻāʻī ʻana o ka ʻiʻo iwi, ka ʻiʻo spasm a me ka myotonia i hoʻokumu ʻia e ka lolo a me ka ʻeha spinal cord, cerebral hemorrhage, encephalitis a me nā sclerosis lehulehu.
Pharmacology
Hoʻemi ʻo ia i ka hoʻokuʻu ʻana o nā waikawa amino excitatory mai nā interneurons a pale i ka hana multi synaptic e pili ana i ka overstrain muscle. ʻAʻole pili kēia huahana i ka lawe ʻana i ka neuromuscular. Ua ʻae maikaʻi ʻia. He mea maikaʻi ia no nā ʻiʻo ʻehaʻeha a me ka ankylosis maʻi mai ka spinal cord a me ka lolo. Hiki iā ia ke hoʻemi i ke kū'ē o ka neʻe passive, hoʻemi i ka spasticity a me ka clonus, a hoʻonui i ka ikaika o ka neʻe ʻana.
Hoʻohana
Lepili ʻia ʻo Tizanidine, i manaʻo ʻia no ka hoʻohana ʻana ma ke ʻano he kūlana kūloko no ka helu ʻana o Tizanidine e GC- a i ʻole LC-mass spectrometry. Hiki iā Tizanidine ke hoʻohana therapeutic ma ke ʻano he mea pale protease nui SARS-CoV-2.
Hoʻohana lāʻau lapaʻau
ʻO Tizanidine kahi agonist adrenergic α2 receptor agonist i hoʻohana ʻia no ka mālama ʻana i nā kūlana spasticity muscle mau, e like me ka maʻi sclerosis.
Mechanism o ka hana
ʻO Tizanidine kahi analogue hoʻomaha hoʻomaha o ka ʻiʻo o ka clonidine i ʻae ʻia no ka hoʻohana ʻana i ka hoʻohaʻahaʻa ʻana i ka spasticity e pili ana i ka ʻeha cerebral a i ʻole spinal cord. ʻO kāna hana hana no ka hōʻemi ʻana i ka spasticity e hōʻike ana i ka presynaptic inhibition o nā neuron motor ma kaα2-adrenergic receptor paena, hoemi i ka hoʻokuʻu 'ana o excitatory aminoʻakika a inhibiting facilitatory ceruleospinal alahele, pela ka hopena i ka ho'ēmiʻana i ka spasticity. Loaʻa iā Tizanidine kahi hapa liʻiliʻi o ka hana antihypertensive o clonidine, ma muli paha o ka hana ma kahi pūʻulu kohoα2C-adrenoceptors, i ʻike ʻia ke kuleana no ka hana analgesic a me antispasmodic o imidazolineα2-agonists(20).
