ʻO ka wehewehe pōkole:
Helu CAS: 69004-03-1
Huina molekala:C18H14F3N3O4S
kaumaha molekula:425.38
Hoʻolālā kemika:
| ʻIke Kumu | |
| inoa huahana | Toltrazuril |
| CAS No. | 69004-03-1 |
| kalakala | Keʻokeʻo a aneane keʻokeʻo crystalline pauda |
| Papa | Papa Hanai |
| Waihona | Hoʻopaʻa ʻia i loko o kahi maloʻo, lumi wela |
| Ola Pahu | 2 makahiki |
| Hoʻohana | Pipi, moa, ilio, ia, lio, puaa |
| Pūʻolo | 25kg/pahu |
wehewehe
ʻO Toltrazuril (Baycox®, Procox®) kahi lāʻau triazinon i loaʻa i ka anticoccidial ākea a me ka antiprotozoalactivity. ʻAʻole hiki ke kūʻai ʻia ma ʻAmelika Hui Pū ʻIa, akā aia ma nā ʻāina ʻē aʻe. Hoʻoikaika ia e kūʻē i nā pae asexual a me ka moekolohe o ka coccidia ma ke kāohi ʻana i ka mahele nuklea o nā schizonts a me nā microga-monts a me nā kino hana pā o nā macrogamonts. Hiki ke hoʻohana ʻia i ka mālama ʻana i ka porcinecoccidiosis neonatal, EPM, a me ka hepatozoonosis canine.
ʻO Toltrazuril a me kāna ponazuril metabolite nui (toltrazuril sulfone, Marquis) he mau lāʻau antiprotozoal i hoʻokumu ʻia i ka triazine i loaʻa ka hana kūikawā e kūʻē i nā maʻi coccidial apicomplexan. ʻAʻole loaʻa ka Toltrazuril i loko o ʻAmelika Hui Pū ʻIa.
Hoʻohana i ka huahana
Puaʻa: Ua hōʻike ʻia ʻo Toltrazuril e hōʻemi i nā hōʻailona o ka coccidiosis i nā puaʻa hānai maʻi kūlohelohe ke hāʻawi ʻia kahi waha waha 20-30 mg / kg BWdose i nā puaʻa 3 a 6 mau lā (Driesen et al., 1995). Ua hōʻemi ʻia nā hōʻailona maʻi mai ka 71 a i ka 22% o nā puaʻa hānai, a ua hoʻemi pū ʻia ka maʻi maʻi a me ka oocyst excretion e ka mālama waha hoʻokahi. ʻO nā huahana i ʻae ʻia e lawe i kahi manawa hoʻihoʻi 77 lā ma United Kingdom.
ʻO nā keiki bipi a me nā keiki hipa: Hoʻohana ʻia ʻo Toltrazuril no ka pale ʻana i nā hōʻailona lapaʻau o ka coccidiosis a me ka hōʻemi ʻana o ka hoʻokahe ʻana o ka coccidia i nā keiki bipi a me nā keiki hipa ma ke ʻano he hoʻokahi lāʻau lapaʻau. ʻO nā manawa hoʻihoʻi ma United Kingdom he 63 a me 42 mau lā no nā keiki bipi a me nā keiki hipa.
Nā ʻīlio: No ka maʻi hepatozoonosis, hāʻawi waha ʻia ka toltrazuril ma 5 mg/kg BW i kēlā me kēia 12 hola no 5 mau lā a i ʻole hāʻawi waha ʻia ma 10 mg/kg BW i kēlā me kēia 12 hola no 10 mau lā i kala ʻia nā hōʻailona maʻi i nā ʻīlio maʻi kūlohelohe i nā lā 2-3 ( Macintire et al., 2001). ʻO ka mea pōʻino, ua hoʻi hou ka hapa nui o nā ʻīlio i mālama ʻia a make i ka hepatozoonosis. I nā ʻīlio me Isospora sp. ʻO ka maʻi, ka mālama ʻana me 0.45 mg emodepside i hui pū ʻia me 9 mg/kg BW toltrazuril (Procox®, Bayer Animal Health) hoʻemi i ka helu oocyst fecal e 91.5-100%. ʻAʻohe ʻokoʻa i ka lōʻihi o ka maʻi maʻi i ka wā i hoʻomaka ai ka mālama ʻana ma hope o ka hoʻomaka ʻana o nā hōʻailona maʻi i ka wā o ka maʻi patent (Altreuther et al., 2011).
Nā pōpoki: I loko o nā pōpoki i hoʻāʻo ʻia me Isospora spp., ʻo ka mālama ʻana me ka waha waha hoʻokahi o 0.9 mg emodepside i hui pū ʻia me 18 mg/kg BW toltrazuril (Procox®, Bayer AnimalHealth) e hōʻemi i ka hoʻokahe ʻana o ka oocyst ma 96.7–100% inā hāʻawi ʻia i ka wā prepatent. manawa (Petry et al., 2011).
Lio: Ua hoʻohana pū ʻia ʻo Toltrazuril no ka mālama ʻana i ka EPM. He palekana kēia lāʻau lapaʻau, ʻoiai ma nā kau kiʻekiʻe. ʻO nā lāʻau lapaʻau i ʻōlelo ʻia i kēia manawa he 5-10 mg/kg ma ka waha no 28 mau lā. ʻOiai ka maikaʻi o ka toltrazuril, ua emi kona hoʻohana ʻana i nā lio ma muli o ka loaʻa ʻana o nā lāʻau lapaʻau maikaʻi ʻē aʻe.
