ʻO ka wehewehe pōkole:
Helu CAS: 54965-21-8
ʻAno molekala: C12H15N3O2S
kaumaha molekala: 265.333
Hoʻolālā kemika:
wehewehe
ʻO Albendazole (ALBENZA) kahi anthelmintic ākea ākea. Hoʻokomo ʻia ʻo Albendazole chewable tablet i ka papa inoa o ka World Health Organization (WHO) o nā lāʻau lapaʻau koʻikoʻi ma ke ʻano he lāʻau anthelminthic intestinal a antifilarial. Ua hoʻomohala ʻia ka papa Albendazole e SmithKline Animal Health Laboratories a ʻae ʻia e ka US Food and Drug Administration (FDA) i ka makahiki 1996.
He hiki i ka Albendazole ke pepehi loa i na hua o ka whipworm a me ka hookworm a me ka pepehi hapa i na hua Ascaris; Hiki iā ia ke hoʻopau i nā ʻano nematodes parasitizing i loko o nā kino holoholona, a he hopena i ka hoʻopau ʻana a i ʻole ka pepehi pololei ʻana i nā tapeworms a me ka cysticerci. No laila he mea pono i ka mālama ʻana i ka hydatid a me ka ʻōnaehana nerve (cysticercosis) ma muli o ka maʻi o ka ilo puaʻa, a me ka mālama ʻana i ka hookworm, roundworm, pinworm, nematode trichinella, tapeworm, whipworm a me stercoralis nematode.
Pharmacodynamics
ʻO Albendazole kahi ʻano derivatives benzimidazole. Hoʻopili koke ʻia i loko o ka vivo i ka sulfoxide, sulfone a me 2-polyamine sulfone alcohol. Hiki iā ia ke hoʻopau i ka glucose uptake o nā nematodes intestinal, no laila ka hopena o ka glycogen endogenous depletion o ka ilo; I ka manawa like, ke kāohi nei ia i ka hana o ka fumarate reductase, a pēlā e pale ai i ka hana ʻana o ka adenosine triphosphate, i ka hopena o ka make ʻana o nā parasites.
E like me ka mebendazole, ma o ka hana ʻana i ka denaturation o nā microtubules cytoplasmic o nā parasites intestinal a hoʻopaʻa ʻia i ka tubulin, hoʻopiʻi ia i ka halihali intracellular, e hoʻoulu ai i nā ʻāpana endocrine Golgi; Ua hoʻoheheʻe ʻia ka cytoplasm, ka mea e make ai nā parasites.
Hiki i kēia huahana ke pepehi loa i nā hua hookworm, nā hua pinworm, nā hua hulu hipa, nā hua tapeworm a me nā hua huila cysticercosis a pepehi hapa i nā hua Ascaris.
Hoʻohana maʻamau
ʻO Albendazole kahi lāʻau lapaʻau i hoʻohana ʻia e mālama i nā maʻi i hoʻokumu ʻia e nā parasites. Hiki ke hāʻawi ʻia no ka mālama ʻana i kahi maʻi lolo kakaʻikahi (neurocysticercosis) a i ʻole hiki ke hāʻawi ʻia no ka mālama ʻana i kahi maʻi parasitic e kumu ai ka maʻi maʻi nui (microsporidiosis).
Hoʻohana lāʻau lapaʻau
ʻO Albendazole ka nui o ka hana e kū'ē i nā nematodes a me nā cestodes o ka'ōpū, a me ke akepaʻa o Opisthorchis sinensis, Opisthorchis viverrini, a me Clonorchis sinensis. Ua hoʻohana maikaʻi ʻia e kūʻē iā Giardia lamblia. Hoʻohana nui ʻia ia ma ka honua holoʻokoʻa no ka mālama ʻana i ka maʻi intestinalnematode. He kūpono ia ma ke ʻano he lāʻau lapaʻau hoʻokahi no ka ascariasis, nā maʻi hookworm New and Old World, a me trichuriasis. ʻO ka lāʻau lapaʻau nui me ka albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, a me ka maʻi hydatid. ʻO ka maikaʻi o ka albendazole e kūʻē i nā ilo lipi (cestodes) maʻamau ʻoi aku ka loli a me ka liʻiliʻi. He mea maikaʻi nō hoʻi ia i ka mālama ʻana i ka neurocysticercosis cerebral a me spinal, ʻoiai ke hāʻawi ʻia me ka dexamethasone. Manaʻo ʻia ʻo Albendazole no ka mālama ʻana i ka gnathostomiasis.
