ʻO ka wehewehe pōkole:
Helu CAS:55268-74-1
Huina molekala:C19H24N2O2
kaumaha mole:312.41
Hoʻolālā kemika:
| ʻIke Kumu | |
| Inoa mea kūʻai | Praziquantel |
| Papa | Papa lāʻau lapaʻau |
| Ka nana aku | He keʻokeʻo a ʻaneʻane keʻokeʻo ka pauka crystalline |
| Hoʻāʻo | 99% |
| Ola ola | 2 makahiki |
| Hoʻopili | 25kg / pahu |
| Ke ano | Hiki ke hoʻoheheʻe ʻia i loko o ka ethanol a i ʻole dichloromethane.Hiki ke hoʻoheheʻe ʻia i ka wai |
| Kūlana | Hoʻopaʻa ʻia i kahi maloʻo, E mālama i loko o ka paʻukū, ma lalo o -20 ° C |
wehewehe
ʻO Praziquantel (PZQ) he isoquinoline derivative me ka hapa nui o ka hana olaola i loaʻa i ka levo enantiomer.ʻAʻohe hana o ka hui e kūʻē i nā nematodes, akā maikaʻi loa ia i nā cestodes a me trematodes.
Pharmacology a me ka hana o ka hana
ʻO Praziquantel kahi pūhui pyrazinoquinoline i kūkulu mua ʻia no ka mālama ʻana i ka schistosomiasis akā ua ʻike ʻia he ākea ākea o ka hana anthelminthic.He racemate ʻo Praziquantel akā ʻo ka R (+) enantiomer wale nō ke kuleana o kāna hana antiparasitic.He mea ikaika ia i nā trematodes (nā ʻano Schistosoma a pau pathogenic i ke kanaka, Paragonimus westermani, a me Clonorchis sinensis) a me nā cestodes (Taenia saginata, Taenia solium, Hymenolepis nana a me Diphyllobothrium latum) .
ʻAʻole ʻike maopopo ʻia ke ʻano o ka hana o praziquantel.Lawe koke ʻo Schistosomes i ka lāʻau lapaʻau.Hoʻopau koke ʻia ka lawe ʻana i ka lāʻau me ka hoʻonui ʻana i ka hana muscular e hele ana i ka ʻokiʻoki tetanic a me ka vacuolization o ka tegument parasite.
ʻO nā hopena muscular o ka lāʻau i manaʻo ʻia ke kuleana o ka neʻe ʻana o nā parasites mai nā veins mesenteric i ke ake i loko o vivo.Eia naʻe, ua hōʻike ʻia ka hoʻololi ʻana o ka hepatic me nā schistososomicides i ʻike ʻia a ʻaʻole hiki ke hāʻawi i kekahi ʻike kikoʻī o ke ʻano hana o ka lāʻau.Ua hōʻike ʻia nā ʻike hoʻokolohua hou e pili ana nā hopena antischistosomal o ka lāʻau i kona hopena i ka tegument ma mua o ka musculature.
ʻO kekahi hopena pharmacological o ka lāʻau lapaʻau e pili ana i ka piʻi ʻana o ka membrane permeability i nā cations, ʻoi aku ka calcium.
Eia naʻe, ʻaʻole ʻike ʻia ke kuleana o kēia hopena i ka waiwai anthelminthic o ka lāʻau.
Palapala noi
He ʻano lāʻau lapaʻau anti-parasitic ākea ākea.Hiki ke hoʻohana ʻia no ka mālama ʻana a me ka pale ʻana i ka schistosomiasis, cysticercosis, paragonimiasis, maʻi hydatid, fasciolopsiasis, maʻi hydatid, a me ka maʻi ilo.
Hiki ke hoʻohana ʻia ma ke ʻano he anthelmintic a maikaʻi i ka mālama ʻana i nā nematodes gastrointestinal holoholona.Hiki ke hoʻohuiʻia i loko o ka hānai no ka noi.
ʻO ka huahana he ʻano lāʻau anthelmintic kūpono i ka mālama ʻana iā Schistosoma japonicum, Schistosoma mansoni a me Schistosoma haematobium, Clonorchis sinensis, Paragonimus westermani, fasciolopsis buski, tapeworms a me cysticercosis.He hopena pepehi ikaika loa ia ma ka tapeworm a i kēia manawa ʻoi aku ka maikaʻi ma waena o ka lāʻau anti-schistosomiasis.
He ʻano lāʻau anthelmintics i hoʻohana nui ʻia no ka mālama ʻana i ka schistosomiasis.Hiki ke hoʻohana ʻia no ka mālama ʻana i ka schistosomiasis Fahrenheit, taeniasis, paragonimiasis, a me cysticercosis.
