ʻO ka wehewehe pōkole:
Helu CAS:590-63-6
ʻAno molekala:C7H17ClN2O2
kaumaha molekala:196.68
Hoʻolālā kemika:
| ʻIke Kumu | |
| inoa huahana | Betanekola |
| Papa | Papa lāʻau lapaʻau |
| Ka nana aku | pauda keʻokeʻo |
| Hoʻāʻo | 95% |
| Ola ola | 2 makahiki |
| Hoʻopili | 25kg / pahu |
| Kūlana | Wahi Puanu me Maloo |
wehewehe
ʻO Bethanechol kahi ester synthetic i pili i ka acetylcholine a me ka pharmacologically. ʻO kahi agonist muscarinic hydrolyzed lohi me ka hopena nicotinic ʻole, hoʻohana maʻamau ʻo bethanechol e hoʻonui i ke kani ʻana o ka ʻiʻo, e like me ka GI tract ma hope o ka ʻoki ʻana a i ʻole ka paʻa ʻana o ka mimi me ka ʻole o ke keakea. Hiki iā ia ke hoʻoulu i ka hypotension, nā loli o ka naʻau, a me nā spasms bronchial.
ʻO Bethanechol kahi agonist o muscarinic acetylcholine receptors me nā waiwai IC50 o 1,837, 25, 631, 317, a me 393 μM no M1-5, i loko o kahi hōʻike hoʻopaʻa radioligand me ka hoʻohana ʻana i nā cell CHO e hōʻike ana i nā mea loaʻa kanaka. Kāohi ia i ka piʻi ʻana o ka M2-mediated AMP cyclic i hoʻokomo ʻia e ka isoproterenol i loko o ka ʻōpū liʻiliʻi puaʻa guinea (IC50 = 127 μM). Hoʻonui ʻo Bethanchol i ka leo basal o ka porcine intravesical ureter (EC50 = 4.27 μM). Hoʻokomo pū ia i ka hoʻoheheʻe ʻana o ka wai i loko o ka ileum, duodenum, a me ka jejunum o nā ʻiole anesthetized i ka wā i lawelawe ʻia ma kahi ʻano o 60 μg/kg. Ua hoʻohana ʻia nā ʻano hana i loaʻa i ka bethanechol no ka hoʻonui ʻana i ka mimi a hoʻomaikaʻi i ke kani ʻana o ka ʻiʻo ma ka ʻōpū o ka ʻōpū.
Hoʻohana lāʻau lapaʻau
ʻO ka hoʻohana nui ʻana o ka bethanechol chloride i ka mālama ʻana i ka paʻa ʻana o ka ʻōpū a me ka hoʻohaʻahaʻa ʻana o ka ʻōpū ma hope o ka hana ʻana. ʻAʻole pono e lawelawe ʻia e ka intramuscular a i ʻole intravenous injection ma muli o ka pōʻino mai ka hoʻoulu ʻana o cholinergic a me ka nalowale o ka hana koho. Hoʻopili ʻia ka lawelawe kūpono ʻana i ka lāʻau me ka haʻahaʻa haʻahaʻa a ʻaʻohe hopena koʻikoʻi. Pono e hoʻohana ʻia ʻo Bethanechol chloride me ka makaʻala i nā maʻi maʻi insthmatic; ke hoʻohana ʻia no ka glaucoma, hoʻopuka ʻo ia i ka ʻeha poʻo mua mai ka hoʻopaʻa ʻana o ka sphinctermuscle i ka maka a mai nā ʻiʻo ciliary. ʻO ka lōʻihi o kāna hana he 1 hola.
Laau Laau Laau Laau a me na Laau Laau Laau
I ka lāʻau lapaʻau holoholona, hoʻohana mua ʻia ka bethanechol e hoʻoulu i ka ʻoki ʻana o ka ʻōpū i nā holoholona liʻiliʻi. Hiki ke hoʻohana ʻia ma ke ʻano he esophageal a i ʻole ka mea hoʻoulu GI maʻamau, ʻoiai metoclopramide a / a i ʻole neostigmine i hoʻololi nui iā ia no kēia mau hoʻohana.
