ʻO ka wehewehe pōkole:
Helu CAS:472-15-1
Huina molekala:C30H48O3
kaumaha molekala:456.71
Hoʻolālā kemika:
| ʻIke Kumu | |
| inoa huahana | ʻakika Betulinic |
| Papa | Papa lāʻau lapaʻau |
| Ka nana aku | Keʻokeʻo a keʻokeʻo paha |
| Hoʻāʻo | 98% |
| Ola ola | 2 makahiki |
| Hoʻopili | 25kg / pahu |
| Kūlana | Paʻa, akā mālama mālie. ʻAʻole kūpono me nā mea hoʻoheheʻe ikaika, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B hui sodium vitamina. |
wehewehe
ʻO ka ʻakika Betulinic (472-15-1) he Lupane triterpenoid maoli mai ka lāʻau birch keʻokeʻo (Betula pubescens). Hoʻoulu i ka apoptosis i loko o nā laina kelepona like ʻole.1 Induces mitochondrial permeability transition pore opening.2 ?Acts as chemosensitizer for anticancer drug treatment in chemoresistant colon cancer cell lines.3 Cell permeable.
Hoʻohana
ʻO Betulinic Acid kahi triterpenoid pentacyclic maoli. Hōʻike ʻo Betulinic Acid i ka hana anti-inflammatory a me ka anti-HIV. ʻO ka Betulinic Acid e hoʻoulu i ka apoptosis i loko o nā pūnaewele tumo ma o ka hoʻonāʻana i ke ala mitochondrial o apoptosis ma o ka p53- a me ka CD95-kūʻokoʻa. Hōʻike pū ka Betulinic Acid i ka hana agonist TGR5.
Ua hoʻohana ʻia ʻo Betulinic acid (BetA):
1.e ho'āʻo i kona mau hopena ma ke ʻano he lāʻau antiviral e kūʻē i ka maʻi Dengue (DENV).
2. ma ke ano he sterol regulatory element-binding protein (SREBP) inhibitor e repress the lipid metabolism and proliferation of clear cell renal cell carcinoma (ccRCC) cells.
3. ma ke ʻano he lapaʻau e hoʻāʻo ai i kāna mau waiwai anti-tumor no ka hiki ke ola a me ka apoptotic cell death assays ma nā ʻano myeloma he nui.
Ka noiʻi ʻana i ka maʻi kanesa
ʻO kēia pūhui he triterpene pentacyclic i loaʻa mai nā ʻano Betula a me Zizyphus, e hōʻike ana i ka cytotoxicity koho e kūʻē i nā cell melanoma kanaka (Shoeb2006). Hoʻoulu ia i nā ʻano oxygen reactive, hoʻāla i ka MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, modulates pro-growth transcriptionalactivators, modulates i ka hana o aminopeptidase-N, a ma laila e hoʻoulu ai i ka maʻi kanesa (Desai et al. 2008; Fulda 2008).
Hana Ola
Triterpenoid kūlohelohe e hōʻike ana i ka hana anti-HIV a me ka antitumor. Hoʻoulu i ka hana o nā ʻano oxygen reactive (ROS) a hoʻoulu i ka NF-κ B. Hōʻike i ka hana agonist TRG5 (EC 50 = 1.04 μ M).
Nā Hana Biochem/physiol
ʻO ka Betulinic acid, he pentacyclic triterpene, e hoʻoulu koho i ka apoptosis i loko o nā pūnaewele tumo ma o ka hoʻolalelale ʻana i ke ala mitochondrial o apoptosis ma o ka p53- a me CD95-kūʻokoʻa.
