ʻO ka wehewehe pōkole:
Helu CAS: 38821-53-3
Huina mole: C16H19N3O4S
kaumaha molekalale: 349.4
Hoʻolālā kemika:
| ʻIke Kumu | |
| inoa huahana | Cefradine |
| Paʻa | Māmā Māmā |
| Ka nana aku | Pauda keʻokeʻo |
| Hoʻāʻo | 99% |
| Lae hehee | 140-142 C |
| Hoʻopili | 5 KG;1 KG |
| Lae paila | 898 ℃ |
wehewehe
ʻO Cefradine (ʻike pū ʻia he cephradine), 7-[D-2-amino-2(1,4cyclohexadien1-yl) acetamido]-3-methyl-8-0x0-5thia-l-azabicyclo [4.2.0] oct-2- ʻO ka ene-2-carboxylic acid monohydrate (111 he semi-synthetic cephalosporin antibiotic. hoʻohana waha, intramuscularly, a intravenously. Ua like ke ʻano o ka cephradine me ka cephalexin, ʻo ka ʻokoʻa wale nō i loko o ke apo ʻeono. He ʻekolu ʻo Cephalexin. ʻO nā paʻa paʻalua e hoʻokumu ana i kahi ʻōnaehana ʻala a ʻo ka cephradine he ʻelua mau paʻa pālua i ka apo hoʻokahi[1].
Kiʻi 1 ke kinona o ka cefradine;
ʻO Cephradine kahi pauka keʻokeʻo keʻokeʻo me ke kaumaha molekala o 349.4[2]. Ua kūkākūkā ʻia ka synthesis o cephradine[3]. Hiki ke hoʻoheheʻe ʻia ʻo Cephradine i loko o nā mea hoʻoheheʻe wai. He zwitterion ia, loaʻa nā pūʻulu amino alkaline a me kahi hui carboxyl acidic. Ma ka pae pH o 3-7, aia ka cephradine ma ke ʻano he paʻakai kūloko[4]. Paʻa ʻo Cephradine no 24 mau hola ma 25" i loko o ka pae pH o 2-8. No ka mea paʻa i loko o ka media acidic, ʻaʻohe liʻiliʻi o ka hana i loko o ka wai ʻōpū; ua hōʻike ʻia nā poho ma lalo o 7%.[5].
Hoʻopaʻa haʻahaʻa ʻia ʻo Cephradine i nā protein serum kanaka. ʻO ka lāʻau lapaʻau ma lalo o 20% i hoʻopaʻa ʻia i nā protein serum[4]. Ma kahi hoʻonui serum o 10-12 pg / ml, 6% o ka nui o ka lāʻau i loko o ka paʻakikī paʻa i ka protein. ʻO kekahi haʻawina[6]ua ʻike ʻia ma ka huina o 10 pg / ml, 28% o ka lāʻau i loko o ka mokuʻāina paʻa i ka protein; i ka huina nui o 100 pg / ml, 30% o ka lāʻau i loko o ka mokuʻāina paʻa i ka protein. Ua hōʻike pū ʻia kēia haʻawina i ka hoʻohui ʻana o ka serum i ka cephradine i hoʻemi i ka hana antibiotic. ʻO kekahi haʻawina[2]hōʻike i ka hoʻopaʻa ʻana o ka protein i ka cephradine mai 8 a 20%, ma muli o ke ʻano o ka lāʻau. Eia naʻe, kahi haʻawina a Gadebusch et al.[5]ʻAʻole i loaʻa kahi loli i ka MIC o cephradine e pili ana i Staphylococcus aureus a i ʻole Escherichia coli ma hope o ka hoʻohui ʻana i ka serum kanaka.
Nā hōʻailona
Hoʻoikaika ka Cephradine i loko o ka vitro e kū'ē i kahi ākea ākea o ka gram-positive a me ka gram-negative bacteria, me nā mea ola pathogenic i hoʻokaʻawale ʻia i loko o ke keʻena; ua hōʻike ʻia ka paʻa o ka waika, a ʻo ka hoʻohui ʻana i ka serum kanaka he hopena liʻiliʻi wale nō ia i ka liʻiliʻi o ka inhibitory concentration (MIC) no nā mea maʻalahi. Ke hāʻawi ʻia ma ka waha a i ʻole ka subcutaneously i nā holoholona i loaʻa i ka hoʻokolohua me nā ʻano bacteria pathogenic, hāʻawi ʻo cephradine i ka pale pono.[16]. I ka mālama ʻana i nā maʻi infective acute, ua hōʻike ʻia nā pane lapaʻau maikaʻi i ka cephradine therapy e kekahi mau mea noiʻi.[14, 15, 17-19].
